Plant Transcription Factor Database
Previous version: v3.0
Klebsormidium flaccidum
bZIP Family
Species TF ID Description
kfl00003_0140bZIP family protein
kfl00015_0390bZIP family protein
kfl00016_0330bZIP family protein
kfl00031_0340bZIP family protein
kfl00048_0210bZIP family protein
kfl00079_0440bZIP family protein
kfl00080_0330bZIP family protein
kfl00098_0290bZIP family protein
kfl00100_0080bZIP family protein
kfl00186_0050bZIP family protein
kfl00215_0090bZIP family protein
kfl00245_0150bZIP family protein
kfl00292_0090bZIP family protein
kfl00342_0010bZIP family protein
kfl00381_0020bZIP family protein
kfl00617_0090bZIP family protein
kfl00698_0060bZIP family protein
bZIP Family Introduction

The bZIP domain consists of two structural features located on a contiguous alpha-helix: first, a basic region of ~ 16 amino acid residues containing a nuclear localization signal followed by an invariant N-x7-R/K motif that contacts the DNA; and, second, a heptad repeat of leucines or other bulky hydrophobic amino acids positioned exactly nine amino acids towards the C-terminus, creating an amphipathic helix. To bind DNA, two subunits adhere via interactions between the hydrophobic sides of their helices, which creates a superimposing coiled-coil structure. The ability to form homo- and heterodimers is influenced by the electrostatic attraction and repulsion of polar residues flanking the hydrophobic interaction surface of the helices.

Plant bZIP proteins preferentially bind to DNA sequences with an ACGT core. Binding specificity is regulated by flanking nucleotides. Plant bZIPs preferentially bind to the A-box (TACGTA), C-box (GACGTC) and G-box (CACGTG), but there are also examples of nonpalindromic binding sites.

Jakoby M, Weisshaar B, Droge-Laser W, Vicente-Carbajosa J, Tiedemann J, Kroj T, Parcy F
bZIP transcription factors in Arabidopsis.
Trends Plant Sci, 2002. 7(3): p. 106-11.
PMID: 11906833